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Concentrations and distribution volumes were initially much greater than values obtained after intravenous injection, but these differences had considerably decreased or disappeared by 2 minutes. Intravenous bolus of I labeled meglumine diatrizoate. A mixture of I labeled meglumine diatrizoate and I labeled human serum albumin was injected into the femoral vein of 26 anesthetized male rats. Measurements of the activities in cardiac blood and in different tissues of the lower extremity and in the testis were performed at time intervals ranging from 5 s to 5 min after injection.

The determination of tissue uptake and distribution volumes of diatrizoate showed widely differing accumulation of contrast medium. Over 50 per cent of the intravenous bolus of diatrizoate was extravascular at 40 s.

Microbial antimony biogeochemistry: Enzymes, regulation, and related metabolic pathways. Antimony Sb is a toxic metalloid that occurs widely at trace concentrations in soil, aquatic systems, and the atmosphere. Nowadays, with the development of its new industrial applications and the corresponding expansion of antimony mining activities, the phenomenon of antimony pollution has become an increasingly serious concern. In recent years, research interest in Sb has been growing and reflects a fundamental scientific concern regarding Sb in the environment.

In this review, we summarize the recent research on bacterial antimony transformations, especially those regarding antimony uptake, efflux, antimonite oxidation, and antimonate reduction. We conclude that our current understanding of antimony biochemistry and biogeochemistry is roughly equivalent to where that of arsenic was some 20 years ago. Arsenic and antimony transporters in eukaryotes.

Arsenic and antimony are toxic metalloids, naturally present in the environment and all organisms have developed pathways for their detoxification. The most effective metalloid tolerance systems in eukaryotes include downregulation of metalloid uptake, efflux out of the cell, and complexation with phytochelatin or glutathione followed by sequestration into the vacuole.

Understanding of arsenic and antimony transport system is of high importance due to the increasing usage of arsenic-based drugs in the treatment of certain types of cancer and diseases caused by protozoan parasites as well as for the development of bio- and phytoremediation strategies for metalloid polluted areas. However, in contrast to prokaryotes, the knowledge about specific transporters of arsenic and antimony and the mechanisms of metalloid transport in eukaryotes has been very limited for a long time.

Here, we review the recent advances in understanding of arsenic and antimony transport pathways in eukaryotes, including a dual role of aquaglyceroporins in uptake and efflux of metalloids, elucidation of arsenic transport mechanism by the yeast Acr3 transporter and its role in arsenic hyperaccumulation in ferns, identification of vacuolar transporters of arsenic-phytochelatin complexes in plants and forms of arsenic substrates recognized by mammalian ABC transporters. Characterization of defects in copper antimony disulfide.

Copper antimony disulfide CuSbS 2 has several excellent bulk optoelectronic properties for photovoltaic absorber applications. Here, we report on the defect properties in CuSbS 2thin film materials and photovoltaic devices studied using several experimental methods supported by theoretical calculations.

Arsenic and Antimony Transporters in Eukaryotes. Pharmacokinetics of multiple doses of transdermal flunixin meglumine in adult Holstein dairy cows. A transdermal formulation of the nonsteroidal anti-inflammatory drug, flunixin meglumine , has been approved in the United States and Canada for single-dose administration. Transdermal flunixin meglumine was administered to 10 adult Holstein cows in their second or third lactation at the label dose of 3.

Plasma flunixin concentrations were determined using high-pressure liquid chromatography with mass spectroscopy HPLC-MS. Pharmacokinetic analysis was completed on each individual animal with noncompartmental methods using computer software. The time to maximum drug concentration Tmax was 2. The mean accumulation factor was 1. This indicates changes in dosing may not be required when giving multiple doses of flunixin transdermal.

Further work is required to investigate the clinical efficacy of transdermal flunixin after multiple daily doses. Intestinal obstruction and constipation are common conditions in patients with advanced neoplasms. Diatrizoate Meglumine has been used in the management of both these conditions without good quality evidence of its effectiveness and safety.

This audit aimed to assess the usage, effectiveness and adverse effects of Diatrizoate Meglumine for intestinal obstruction and constipation in patients with advanced neoplasms. A retrospective chart review was undertaken. Descriptive statistics were utilised. Seventy-one patients received Diatrizoate Meglumine. The most common diagnoses were ovarian or primary peritoneal neoplasms Diatrizoate Meglumine was most commonly used for intestinal obstruction Diatrizoate Meglumine was well tolerated and may be effective in resolving intestinal obstruction and constipation in patients with advanced neoplasms.

Quality controlled studies are needed to further guide the use of Diatrizoate Meglumine in intestinal obstruction and constipation in patients with advanced neoplasms. Acute metabolic responses to a combined viral-bacterial respiratory disease challenge in heifers administered transdermal flunixin meglumine. A trial was conducted to determine effects of altering time of transdermal flunixin meglumine BTD; Banamine Transdermal, Merck Animal Health, Summit, NJ administration relative to a viral-bacterial respiratory disease challenge in beef heifers.

Acute immunological responses to a combined viral-bacterial respiratory disease challenge in heifers administered transdermal flunixin meglumine. Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses. The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques.

Effective renal plasma flow ERPF and effective renal blood flow ERBF were determined by plasma clearance of I-orthoiodohippuric acid before and after administration of flunixin meglumine. Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: A systematic review. Background The mainstays of cutaneous leishmaniasis CL treatment, in several world regions, are pentavalent antimony Sbv compounds administered parenterally, despite their recognized toxicity, which requires frequent laboratory monitoring and complicates their use in areas with scarce infrastructure.

As result of these drawbacks, the WHO Expert Committee on leishmaniasis has expanded the recommendations for the use of local therapies, including Sbv intralesional infiltration IL-Sbv , as CL therapy alternatives even in the New World.

However, the efficacy of these approaches has never been compiled. The aim of this study was to critically and systematically assess the efficacy of IL-Sbv for CL treatment. The outcome of interest was a clinical cure, defined as complete re-epithelialization of all lesions. The IL-Sbv pooled cure rate was estimated for several subgroups and direct comparisons were performed when possible.

Results Thirty nine articles 40 studies involving patients treated with IL-Sbv infiltration were included. Interaction between antimony atoms and micropores in silicon. Odzhaev, V. The interaction between Sb atoms and micropores of a getter layer in silicon is studied. The antimony atoms located in the vicinity of micropores are captured by micropores during gettering annealing and lose its electrical activity.

The activation energy of capture process to the pores for antimony is lower than that of antimony diffusion in silicon deformation fields around microvoids on the diffusion process. Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches. The aim of this study was to compare the effect of flunixin meglumine FM and meloxicam M on postoperative and oxidative stress in ovariohysterectomized bitches.

The concentrations of serum cortisol, nitric oxide NO , malondialdehyde MDA , antioxidant potential AOP and glutation GSH were measured in blood samples collected during incision 0 h , closure of incision line 0. It was observed that cortisol level was higher at 0. Therefore, it is suggested that postoperative stress following ovariohysterectomy may be prevented by flunixin meglumine. Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration.

Appropriate pain management for lameness in swine is a critical control point for veterinarians and producers, but science-based guidance on optimal housing, management and treatment of lameness is deficient. Results No adverse effects were observed with flunixin meglumine administration for all routes.

Flunixin meglumine was administered at an actual mean dose of 2. TMAX was recorded at 1. Conclusions The results of the present study suggest that FM oral administration is not the most effective administration route for mature swine when compared to IV and IM.

Leishmaniasis is a group of diseases that presents various clinical manifestations. Many studies have shown that the parasite plays an important role in the clinical manifestations and prognosis of this disease. The cutaneous and mucosal forms of American tegumentary leishmaniasis ATL are associated with Leishmania Viannia braziliensis, which exhibits intraspecific genetic polymorphisms and various clinical manifestations.

The present study focused on four different L. The isolates were described based on their molecular, biological, and infective characteristics. Complement resistance was evaluated using guinea pig serum. Infection to murine peritoneal macrophages, cytokine and nitric oxide were analyzed.

Ultrastructural features were determined by transmission electron microscopy, and molecular characteristics were determined based on random amplified polymorphic DNA RAPD. All of the L. Markedly lower infectivity indexes were observed for all strains in the LOG phase, with different cytokine profiles. We report the effects of antimony Sb doping on the electrical and optical properties of amorphous carbon a-C:H films grown on silicon and copper substrates by magnetron sputtering deposition.

For film deposition, the mixture targets fabricated from carbon and antimony powders was used. The atomic concentration of carbon, hydrogen, and antimony , in the film deposited from the 1. These elements were homogeneously distributed in the film. On the structural effect, the average continuous sp2 carbon bonding networks decreased with Sb concentration increasing, and defects in the films were increased with the Sb incorporation because atomic radius of Sb atoms is twice larger size than that of carbon.

The optical gap and the electrical resistivity were carried out before and after the Sb doping. The results show that optical gap dropped from 3. The electrical resistivity reduced from These results suggest the doping level was newly formed in the forbidden band. Serum electrolyte and protein changes after intravenous injection of sodium and meglumine diatrizoate urograffin Serum electrolyte and protein changes in 35 Nigerian patients undergoing intravenous urography were evaluated after injection of 60 mls sodium and meglumine diatrizoate Urograffin Statistically, significant changes were noted in the values of serum calcium, proteins and albumin at 5 and 30 minutes after the injection P A Pharmacokinetics, Efficacy, and Safety Study of Gadoterate Meglumine in Pediatric Subjects Aged Younger Than 2 Years.

Objectives The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. Material and Methods This was a Phase IV open-label, prospective study conducted in 9 centers 4 countries. Forty-five patients younger than 2 years with normal estimated glomerular filtration rate and scheduled to undergo routine gadolinium-enhanced magnetic resonance imaging MRI of any organ were included and received a single intravenous injection of gadoterate meglumine 0.

To perform the population pharmacokinetics analysis, 3 blood samples per subject were drawn during 3 time windows at time points allocated by randomization. Results Gadoterate meglumine concentrations were best fitted using a 2-compartmental model with linear elimination from central compartment. The median total clearance adjusted to body weight was estimated at 0. The median volume of distribution at steady state Vss adjusted to body weight was estimated at 0. Lesion visualization was improved with a mean SD increase in scores at subject level of 0.

Twenty-six adverse events occurred postinjection in 13 subjects The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. This was a Phase IV open-label, prospective study conducted in 9 centers 4 countries. Gadoterate meglumine concentrations were best fitted using a 2-compartmental model with linear elimination from central compartment.

One subject 2. In vitro antileishmanial activity of fisetin flavonoid via inhibition of glutathione biosynthesis and arginase activity in Leishmania infantum. With the increasing emergence of drug resistant Leishmania sp. The present study was designed to evaluate the antileishmanial effects of the fisetin alone and combination of fisetin plus Meglumine antimoniate Fi-MA against Leishmania infantum.

The IC50 values for fisetin were obtained 0. The decreased levels of most of the antioxidant enzymes, accompanying by the raised level of NO in treated macrophages with MA, were observed to regain their normal profiles due to Fi-MA treatment. In conclusion, these findings showed that fisetin improves MA side effects. The exposure to and health effects of antimony.

Context: This minireview describes the health effects of antimony exposure in the workplace and the environment. Aim: To collate information on the consequences of occupational and environmental exposure to antimony on physiological function and well-being. Methods: The criteria used in the current minireview for selecting articles were adopted from proposed criteria in The International Classification of Functioning, Disability and Health. Articles were classified from an acute and chronic exposure and toxicity thrust.

Results: The proportion of utilised and non-utilised articles was tabulated. Antimony toxicity is dependent on the exposure dose, duration, route breathing, eating, drinking, or skin contact , other chemical exposures, age, sex, nutritional status, family traits, life style, and state of health.

Long-term inhalation of antimony can potentiate pneumoconiosis, altered electrocardiograms, stomach pain, diarrhea, vomiting, and stomach ulcers, results which were confirmed in laboratory animals. Although there were investigations of the effect of antimony in sudden infant death syndrome, current findings suggest no link.

Antimony trioxide exposure is predominant in smelters. Mining and exposure via glass working, soldering, and brazing are also important. Conclusion: Antimony has some useful but undoubtedly harmful effects on health and well-being and measures need to be taken to prevent hazardous exposure of the like. Its biological monitoring in the workplace is essential. The first line drug against leishmaniasis consists of pentavalent antimony [Sb V ], but there is general belief that the active form of the metal is the trivalent form [Sb III ].

In this study, we have quantified the accumulation of Sb V and Sb III in Leishmania by using inductively coupled plasma mass spectrometry. The accumulation was studied in three Leishmania species at various life stages, sensitive or resistant to antimony.

The level of accumulation of either Sb III or Sb V , however, was not correlated with the susceptibility of wild-type Leishmania cells to antimony. This suggests that other factors may also be implicated in the mode of action of the drugs. In contrast to metal susceptibility, resistance to Sb III correlated well with decreased antimony accumulation. This phenotype was energy dependent and highlights the importance of transport systems in drug resistance of this protozoan parasite.

Comparison of the excretion of sodium and meglumine diatrizoate at urography with simulated compression: an experimental study in the rat. In the experimental model in the rabbit the excretion of sodium and meglumine diatrizoate, respectively, have been compared. More reliable dose optima are probably found when calculating density rather than determining urine concentrations.

Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey. To determine whether cull dairy cows with signs of certain clinical conditions, termed suspect, are more likely than healthy-appearing cull dairy cows to have violative concentrations of flunixin meglumine in their tissues at slaughter. Cross-sectional study. Suspect cull dairy cows were selected from 21 beef slaughter establishments with a high production volume of dairy cows, and kidney and liver tissues were collected for screening.

Kidney tissues were screened for antibiotics and sulfonamides with the fast antimicrobial screening test FAST. During the same time period, liver tissues from healthy-appearing cull dairy cows were collected for the Food Safety and Inspection Service National Residue Program Scheduled Sampling Plan, but were screened only for flunixin meglumine.

Of suspect cull dairy cows, 50 7. Thirty-one of Two of the 0. Suspect cull dairy cows, especially those that were also FAST positive, had a significantly higher incidence of violative tissue flunixin concentrations than healthy-appearing cull dairy cows at slaughter. Targeted sampling plans for flunixin meglumine in suspect dairy cows can help to support more efficient use of resources and further safeguard the nation's food supply.

Prospective randomized trial of iohexol versus meglumine sodium diatrizoate as an oral contrast agent for abdominopelvic computed tomography. To compare the efficacy and patient tolerance of iohexol and meglumine sodium diatrizoate as oral contrast agents for computed tomography CT.

One hundred patients were randomly assigned to drink mL of either meglumine sodium diatrizoate or iohexol before their abdominopelvic CT examination. The images were evaluated independently and in a blinded fashion by 2 radiologists who scored the extent and density of bowel opacification.

Attenuation value measurements were obtained in representative areas of each gastrointestinal tract segment stomach, duodenum, jejunum, ileum, and colon by a research technologist. Patients' tolerance of the oral contrast agent was assessed through a questionnaire administered immediately after the CT and with a follow-up phone call 2 to 3 days later. For most of the bowel, there was no statistically significant difference in the extent or degree of opacification between the 2 contrast agents.

Opacification of the ileum was better with iohexol. There was no statistically significant difference between the 2 agents in adverse effects. Patients had a small but statistically significant preference for the taste of iohexol.

Iohexol is a satisfactory oral contrast agent for abdominopelvic CT. It opacifies the gastrointestinal tract as well as meglumine sodium diatrizoate does, and patients prefer the taste of iohexol to that of diatrizoate. Antimony diffusion in CdTe. Group V dopants may be used for next-generation high-voltage cadmium telluride CdTe solar photovoltaics, but fundamental defect energetics and kinetics need to be understood.

Here, antimony Sb diffusion is studied in single-crystal and polycrystalline CdTe under Cd-rich conditions. Diffusion profiles are determined by dynamic secondary ion mass spectroscopy and analyzed with analytical bulk and grain-boundary diffusion models. Slow bulk and fast grain-boundary diffusion are found. Density functional theory is used to understand formation energy and mechanisms. Lastly, the theory and experimental results create new understanding of group V defect kinetics in CdTe.

Effect of flunixin meglumine and carprofen on pregnancy rates in dairy cattle. Embryonic losses contribute considerably to low pregnancy rates. Flunixin meglumine FM has been demonstrated to delay luteolysis and to support embryonic survival. The objective of this study was to evaluate the effect of FM and carprofen on conception rates in dairy heifers and cows, respectively.

In experiment 1, the effect of FM on pregnancy rates and progesterone concentrations in dairy heifers was tested. A total of heifers were randomly assigned to 1 of 2 groups. Pregnancy rates were In experiment 2, the objective was to verify the effects of carprofen, a longer acting nonsteroidal antiinflammatory drug and to evaluate its effect on conception rate to first service in dairy cows.

A total of cows were randomly assigned to 1 of 2 treatment groups. Pregnancy was diagnosed between d 40 and 47 after insemination. Conception rates to first service were Nuclear orientation of antimony and bromine isotopes. The technique of Low Temperature Nuclear Orientation has been used to study neutron deficient antimony and bromine isotopes. Further anisotropy measurements on [ The magnetic moment of [72]Br has been limited to be within the range 0. Leishmaniasis is a disease that affects 2 million people and kills persons every year.

It is caused by Leishmania species, which are human protozoan parasites of the trypanosomatidae family. The current treatment of leishmaniasis relies mainly on antimonial drugs. The crystal structures of oxidized trypanothione reductase TR from Leishmania infantum and of the complex of reduced TR with NADPH and Sb III , reported in this paper, disclose for the first time the molecular mechanism of action of antimonial drugs against the parasite.

Sb III , which is coordinated by the two redox-active catalytic cysteine residues Cys52 and Cys57 , one threonine residue Thr , and His' of the 2-fold symmetry related subunit in the dimer, strongly inhibits TR activity.

Because TR is essential for the parasite survival and virulence and it is absent in mammalian cells, these findings provide insights toward the design of new more affordable and less toxic drugs against Leishmaniasis. Antimony ore in the Fairbanks district, Alaska. Antimony -bearing ores in the Fairbanks district, Alaska, are found principally in two areas, the extremities of which are at points 10 miles west and 23 miles northeast of Fairbanks; and one of two minor areas lies along this same trend 30 miles farther to the northeast.

These areas are probably only local manifestations of mineralization that affected a much broader area and formed antimony -bearing deposits in neighboring districts, the closest of which is 50 miles away. The ores were exposed largely as a result of lode gold mining, but at two periods in the past, high prices for antimony ore warranted an independent production and about tons of stibnite ore was shipped.

The sulfide deposits occupy the same fractures along which a gold-quartz mineralization of greater economic importance occurred; and both are probably genetically related to igneous rocks which intrude the schistose country rock. The sulfide is in part contemporaneous with some late-stage quartz in which it occurs as disseminated crystals; and in part the latest filling in the mineralized zones where it forms kidney-shaped masses of essentially solid sulfide.

One extremely long mass must have contained nearly tons of ore, but the average of the larger kidneys is closer to several tons. Much of the ore is stibnite, with quartz as a minor impurity, and assays show the tenor to vary from 40 to 65 percent antimony. Sulphantimonites are less abundant but likewise occur as disseminated crystals and as kidney-shaped bodies. Antimony oxides appear on the weathered surface and along fractures within the sulfide ore.

Deposits containing either stibnite or sulphantimonite are known at more than 50 localities, but only eighteen have produced ore and the bulk of this came from the mines. The geology of the deposit, and the nature, extent, and period of the workings are covered in the detailed descriptions of individual occurrences. Several geologic and economic factors, which greatly affect. The creation and exchange of biologically relevant models is of great interest to many researchers.

When multiple standards are in use, models are more readily used and re-used if there exist robust translators between the various accepted formats. Antimony 2. All provided unique challenges, stemming from differences in each format's inherent design, in addition to differences in functionality. Topical terbinafine in the treatment of cutaneous leishmaniasis: triple blind randomized clinical trial. Leishmaniasis is a spectrum of disease condition with considerable health impacts, caused by different species of Leishmania.

This disease is currently endemic in 98 countries and territories in the world. There are many treatment modalities for cutaneous leishmaniasis. The use of topical terbinafine in the treatment of cutaneous leishmaniasis has recently been considered. Although, there was no statistically significant different between the two treatment groups, but clinically it seems that the treatment rate in those who receive glucantime plus terbinafine was more effective than the other group.

However this rate depended on the type of lesions. As data indicated ulcerated nodules, papules and plaque in experimental group have been completely improved two times faster than placebo group. Ulcerated nodules, nodules and plaque were partially improved faster in those used tebinafine than placebo ointment.

In vitro enantioselective pharmacodynamics of Carprofen and Flunixin- meglumine in feedlot cattle. These findings are discussed in relation to the prediction of the clinical relevance of COX inhibition by the test drugs in cattle. Preoperative bowel preparation with meglumine and sodium diatrizoate Gastrografin : a prospective randomised comparison. To test the use of meglumine and sodium diatrizoate Gastrografin as an agent for preoperative mechanical bowel preparation.

Prospective randomised comparison. County general hospital, Greece. Tolerability, acceptability, quality of cleansing, and complications. There were no disturbances in electrolyte concentrations, and other laboratory variables also remained unchanged. Two patients treated with Ringer's solution had appreciable increases in arterial blood pressure, but there were no significant overall changes.

About half the patients given Ringer's felt nauseated and a third vomited. Antimony is used as a flame-retardant in textiles and plastics, in semiconductors, pewter, and as pigments in paints, lacquers, glass and pottery. Subacute or chronic antimony poisoning has been reported to cause sleeplessness. Furthermore, we found that higher urinary antimony levels in participants were associated with OSA OR 1.

In this study, we found that urinary antimony was associated with higher odds to have insufficient sleep and OSA. Because of the public health implications of sleep disorders, further studies, especially a prospective cohort study, are warranted to evaluate the association between antimony exposure and sleep-related disorders.

Published by Elsevier Inc. The second method, first-derivative spectrophotometric method 1D , depends on measuring the peak amplitude of the first derivative selectively at and The fourth method, first derivative of ratio spectra method 1DD , depends on measuring the amplitude peak to peak of the first derivative of ratio spectra at Different factors affecting the applied spectrophotometric methods were studied. The proposed methods were validated according to ICH guidelines.

Satisfactory results were obtained for determination of both drugs in laboratory prepared mixture and pharmaceutical dosage form. The developed methods are compared favourably with the official ones. The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine. Drug use in livestock has received increased attention due to welfare concerns and food safety. Characterizing heterogeneity in the way swine populations respond to drugs could allow for group-specific dose or drug recommendations.

Our objective was to determine whether drug clearance differs across genetic backgrounds and sex for sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine. Two sires from each of four breeds were mated to a common sow population. Drugs were administered intravenously and blood collected a minimum of 10 times over 48 h. A non-compartmental analysis of drug and metabolite plasma concentration vs. Within-drug and metabolite analysis of pharmacokinetic parameters included fixed effects of drug administration date, sex and breed of sire.

Breed differences existed for flunixin meglumine P-value 40 CFR The provisions of this Excretory, secretory, and tissue residues after label and extra-label administration of flunixin meglumine to saline or lipopolysaccharide-exposed dairy cows. Five cattle in each group received 3 doses of flunixin meglumine administered by either IV infusion or IM injection at 24 h intervals.

Milk, urine, and tissues were collected The antimony in metallic kitchen ware was determined. In eight metallic samples, antimony was detected in solder used for the production of a can for green tea and an eggbeater. The contents were 1. No antimony was detected in solder used for a cookie cutter. A sample of solder used for electric work, not for food utensils, contained 0. In other metallic utensils which come in contact with food such as aluminum foil, a brass spoon, a stainless steel fork, a wire netting, and an iron rock for vegetable color stabilizing, antimony was not detected at a 0.

A qualitative test using rhodamine B also showed positive results in only three solder samples. Lead concentrations in solder used for the kitchen ware were from No cadmium was detected in any samples.

Antimony photoresists for EUV lithography: mechanistic studies. A series of mechanistic studies followed the production of reaction byproducts by mass spectrometer, as they left the film during exposure to EUV photons and 80 eV electrons. We identified several prominent outgassing fragments and their rates of production as a function of ligand structure. The degree of outgassing appears to be well-correlated with the bond dissociation energy of the carboxylate ligand R' group.

Furthermore, a deuterium labeling study was conducted to determine from which ligand hydrogen is abstracted to form benzene and phenol during exposure. Using the results of the outgassing studies alongside established mechanisms for electron-induced reactions; a series of reaction pathways were proposed to generate the aforementioned outgassing species and a possible nonvolatile negative-tone photoproduct.

Laser resonance ionization spectroscopy of antimony. The resonant ionization laser ion source is an element selective, efficient and versatile ion source to generate radioactive ion beams at on-line mass separator facilities. For some elements with complex atomic structures and incomplete spectroscopic data, laser spectroscopic investigations are required for ionization scheme development. Laser light of Upon the identification of efficient SES, the third excitation steps for resonance ionization were investigated by laser scans across Rydberg states, the ionization potential and autoionizing states.

One Rydberg state and six AI states were found to be well suitable for efficient resonance ionization. Leishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases. There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions. However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alternative molecules.

In this paper, we reviewed the studies carried out on antimonial resistance in Leishmania. Several common limitations of these works are presented before prevalent approaches to evidence antimonial resistance are related. Afterwards, phenotypic determination of resistance is described, then confronted to clinical outcome. Finally, we detail molecular mechanisms and targets involved in resistance and already identified in vitro within selected mutant strains or in clinical isolates.

Antimony recycling in the United States in The importance of recycling has become more obvious as concerns about the environment and import dependence have grown in recent years. When materials are recycled, fewer natural resources are consumed, and less waste products go to landfills or pollute the water and air. This study, one of a series of reports on metals recycling in , discusses the flow of antimony from mining through its uses and disposal with emphasis on recycling.

In , the recycling efficiency for antimony was estimated to be 89 percent, and the recycling rate was about 20 percent. Preparation and characterization of antimony barium composite oxide photocatalysts. In this paper, two kinds of antimony barium composite oxide photocatalysts have been prepared by two methods and characterized by XRD and SEM.

The photocatalytic activity was evaluated by a photocatalytic reactor and an ultraviolet spectrophotometer. In addition, BaSb2O6 morphology showed more regular, microstructure and better catalytic performance. Reductive precipitation of metals photosensitized by tin and antimony porphyrins. A method for reducing metals using a tin or antimony porphyrin by forming an aqueous solution of a tin or antimony porphyrin, an electron donor, such as ethylenediaminetetraaceticacid, triethylamine, triethanolamine, and sodium nitrite, and at least one metal compound selected from a uranium-containing compound, a mercury-containing compound, a copper-containing compound, a lead-containing compound, a gold-containing compound, a silver-containing compound, and a platinum-containing compound through irradiating the aqueous solution with light.

This paper proposes the use of a multisyringe flow injection analysis MSFIA system for inorganic antimony speciation analysis, trimethyl antimony V and determination of total antimony in soil samples using hydride generation atomic fluorescence spectrometry HG-AFS. Total antimony has been determined after reduction of antimony V to antimony III using potassium iodide and ascorbic acid. For determination of total inorganic antimony the sample is percolated in a mini-column containing the Dowex 50W-X8 resin for retention of the organic species of antimony.

Antimony III is quantified in presence of 8-hydroxyquinoline as masking agent for antimony V after an extraction step of the organic antimony species using the also same mini-column. The trimethyl antimony V content is found by difference between total antimony and total inorganic antimony.

By other hand, antimony V is quantified by difference between total inorganic antimony and antimony III. The analytical determinations were performed using sodium tetrahydroborate as reducing agent. The optimization step was performed using two-level full factorial design and Doehlert matrix involving the factors: hydrochloric acid and sodium tetrahydroborate concentrations and sample flow rate.

The optimized experimental conditions allow the antimony determination utilizing the external calibration technique with limits of detection and quantification of 0. The method accuracy was confirmed by analysis of the soil certified reference material furnished from Sigma-Aldrich RTC.

The antimony extraction step was performed in a closed system using hydrochloric acid, ultrasonic radiation and controlled temperature. Antimony , arsenic and mercury in the aquatic environment and fish in a large antimony mining area in Hunan, China. Antimony Sb has received increasing attention recently due to its toxicity and potential human carcinogenicity.

Results show that serious Sb and moderate arsenic As contamination is present in the aquatic environment. The average Sb concentrations in water and fish were The Sb concentration in drinking water exceeded both Chinese and WHO drinking water guidelines by 13 and 3 times, respectively.

Antimony and As concentrations in water varied with seasons. Fish gills exhibited the highest Sb concentrations but the extent of accumulation varied with habitat. Antimony enrichment in fish was significantly lower than that of As and Hg. Copyright Elsevier B. Supra-amphiphiles are a new class of building blocks that are fabricated by means of noncovalent forces. In this work, we studied the formation of supra-amphiphiles by combining hydrophilic meglumine MEG with hydrophobic maleated castor oils MACO.

Spectroscopic analysis demonstrated that ionic interactions are the main driving force in the fabrication of these materials. Micellar and lamellar liquid crystalline phases were observed. Finally, we observed that the supra-amphiphiles produced using an excess of MEG retain a large amount of water. As bound water plays an important role in biointerfacial interactions, we anticipate that these materials will display a pronounced potential for biomedical applications.

Value of water-soluble contrast meglumine amidotrizoate in the diagnosis and management of small bowel obstruction. The object of the present study was to determine the effectiveness of a water-soluble contrast follow-through study for differentiating complete from incomplete small bowel obstruction SBO and for predicting the need for surgery.

All adult patients admitted with SBO were included, except those with obstructed hernias, peritonitis, or postabdominal irradiation. The initial resuscitation meglumine amidotrizoate Gastrografin follow-though was performed and was considered positive for complete obstruction if the contrast failed to reach the colon as shown on the hour film. Patients were operated on only if they developed signs of strangulation or failed to improve within 48 hours.

Our study group consisted of 73 patients, 48 The mean age was In 60 The other 13 Therefore the sensitivity, specificity, positive predictive value, and negative predictive value for meglumine amidotrizoate follow-through as an indicator for operative treatment of SBO were The P value using Fisher's exact test was 0.

We can confidently diagnose complete and incomplete SBO and differentiate one from the other. This accurate diagnosis indicates a high chance of success with conservative management for incomplete obstruction but does not always correlate with the need for surgical intervention.

This substance may cause cardiovascular effects. This substance may cause ocular irritation. Silibinin meglumine , a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition EMT in EGFR-mutant non-small-cell lung carcinoma cells.

Silibinin is the primary active constituent of a crude extract silymarin from milk thistle plant Silybum marianum seeds. We explored the ability of an oral milk thistle extract formulation that was enriched with a water-soluble form of silibinin complexed with the amino-sugar meglumine to inhibit the growth of non-small-cell lung carcinoma NSCLC mouse xenografts.

Concurrent treatment with silibinin meglumine impeded the regrowth of gefitinib-unresponsive tumors, resulting in drastic tumor growth prevention. Silibinin- meglumine efficiently prevented the loss of markers associated with a polarized epithelial phenotype as well as the de novo synthesis of proteins associated with the mesenchymal morphology of transitioning cells. Our current findings with this non-toxic, orally active, and water-soluble silibinin formulation might facilitate the design of clinical trials to test the administration of silibinin meglumine -containing injections, granules, or beverages in combination with EGFR TKIs in patients with EGFR-mutated NSCLC.

A kinetic model for flame inhibition by antimony -halogen compounds in hydrocarbon flames is developed. Thermodynamic data for the relevant species are assembled from the literature, and calculations are performed for a large set of additional species of Sb-Br-C-H-O system. The main Sb- and Br-containing species in the combustion products and reaction zone are determined using flame equilibrium calculations with a set of possible Sb-Br-C-H-O species, and these are used to develop the species and reactions in a detailed kinetic model for antimony flame inhibition.

The complete thermodynamic data set and kinetic mechanism are presented. Laminar burning velocity simulations are used to validate the mechanism against available data in the literature, as well as to explore the relative performance of the antimony -halogen compounds. Further analysis of the premixed flame simulations has unraveled the catalytic radical recombination cycle of antimony. The inhibition cycles of antimony are shown to be more effective than those of bromine, and intermediate between the highly effective agents CF3Br and trimethylphosphate.

The inhibition cycles of antimony are shown to be more effective than those of bromine, and intermediate between the highly effective agents CF 3 Br and trimethylphosphate. Often few alternative anesthetics for exotic species are available, due to the small numbers of these animals used in research. In this study, we evaluated the depth and duration of anesthesia in Xenopus laevis after their immersion in 3 doses of etomidate 15, We then chose an optimal dose for each alternative anesthetic according to induction time, duration of surgical plane, and time to complete recovery.

The optimal etomidate and benzocaine doses Efficacy of the analgesic was assessed at 1, 3, 6, and 24 h postoperatively by using acetic acid testing AAT. Histology of the liver, kidney, and tissues surrounding the dorsal lymph sac was performed at day 3, 14, and 28 in each group of animals. Mild to moderate myocyte degeneration and necrosis were present in tissues surrounding the dorsal lymph sac at both flunixin meglumine doses after etomidate and benzocaine anesthesia.

In conclusion, benzocaine and etomidate offer alternative anesthetic regimens, according to typical requirements for an anesthetic event. Pistacia atlantica is native plant in Iran central, western, and eastern regions. Gum obtained Pistacia atlantica has been reported to possess considerable in vitro antimicrobial activity. In this study, we aimed to investigate antileishmanial activity of P.

Mice were randomly divided into 3 groups. Kurdica were tested by rubbing of local lesions for 28 days, group 3 infected but non-treated. Comparisons of treated groups and untreated group were done by two-way analysis of variance ANOVA Results Topically rubbing administration of gum obtained P. Its aim is to provide a better understanding of biogeochemical cycle disturbances of antimony by man. Specifically, it is focused on the atmosphere-soil-organism interfaces.

Based on a multi-scale approach, the impact of antimony on organisms and organism communities and the factors of Sb dispersion in the environment aim to better characterized. This report gives the main results of 2 and 1 -2 years of research. Using peat bogs as environmental archives, we show that Sb contamination in soils date back to the beginning of the metallurgy.

This disturbance in the antimony geochemical cycle modified its concentrations in soils. One main source of present Sb contamination is automotive traffic due to Sb in braking lines. This emerging contamination was characterized close to a roundabout. Genotoxicity tests have been performed on the model plant Vicia faba and show that antimony is genotoxic at its lowest concentrations and that there is a synergistic effect lead, a trace metal frequently found in association with antimony in the environment.

It is a main issue to determine Sb critical loads in the environment but main identified lacks are thermodynamic data, which are not available yet, to model the behavior of Sb in soil solutions and the fact the antimony is always associated with other anthropogenic trace metals like lead. Critical thresholds of Sb have been determined for the first time based on genotoxicity experiment.

Simulations show that these thresholds can be exceeded in the future, whereas present limits for invertebrates US-EPA are and will not be reached. Antimony can be considered both a critical metal and an environmental hazard, with a toxicity similar to arsenic. It is concentrated in stibnite deposits, but also present in polymetallic and precious metal ores, frequently accompanied by arsenic.

We have studied the mineralogical controls on the mobility of antimony in three types of mine waste: stibnite tailings from an antimony mine, tetrahedrite-bearing waste rock from copper mining, and gold mine tailings and ore roaster waste. Our results demonstrate that the tendency of antimony to leach into the aqueous environment or remain sequestered in solid phases depends on the primary host minerals and conditions governing the precipitation of secondary antimony -hosting phases.

In tailings at the Beaver Brook antimony mine in Newfoundland, Canada, stibnite oxidizes rapidly, and secondary minerals such as the relatively insoluble Sb-Fe tripuhyite-like phase and Sb-bearing goethite. However, under dry conditions, the most important secondary Sb host is the Mg-Sb hydroxide brandholzite, but this easily soluble mineral disappears when it rains.

Finally, the original antimony -hosting minerals, both stibnite and sulphosalts, in the gold ore at Giant Mine, Yellowknife, Canada were completely destroyed during ore roasting. In tailings-contaminated sediments, antimony persists in roaster-generated iron oxide phases, except under reducing conditions where some of the antimony forms a Sb-S phase.

The combined presence of antimony and arsenic in mine waste complicates risk assessment but in general, our findings suggest that antimony is less mobile than arsenic in the environment. Antimony Sb is a naturally occurring toxic element commonly associated with arsenic As in the environment and both elements have similar chemistry and toxicity.

Increasing numbers of studies have focused on microbial As transformations, while microbial Sb interactions are still not well understood. To gain insight into microbial roles in the geochemical cycling of Sb and As, soils from Sb mine tailing were examined for the presence of Sb- and As-oxidizing bacteria.

However, no SbIII oxidation activity was detected from the Sinorhizobium-related isolate, suggesting the involvement of different mechanisms for Sb and As oxidation. These results demonstrate that indigenous microorganisms associated with Sb mine soils are capable of Sb and As oxidation, and potentially contribute to the speciation and mobility of Sb and As in situ.

Correlation of CsK2Sb photocathode lifetime with antimony thickness. Photocathodes were characterized as a function of antimony layer thickness and alkali consumption, inside a vacuum chamber that was initially baked, but frequently vented without re-baking.

Photocathode lifetime measured at low voltage is correlated with the antimony layer thickness. Photocathodes manufactured with comparatively thick antimony layers exhibited the best lifetime. We speculate that the antimony layer serves as a reservoir, or sponge, for the alkali. Antimonial dust is a by-product of lead smelting and an important material for extracting antimony. A new pyrometallurgical process for producing antimony white from the antimonial dust is reported.

The process mainly consists of three steps, which are reduction smelting, alkaline refining, and blowing oxidation. First, the reduction smelting of antimonial dust is carried out in an oxygen-rich bottom blow furnace to enrich antimony and lead in the crude alloy. The antimony and lead contents in the slag can thus be reduced to 2.

Second, the conventional method of alkaline refining is adopted to remove arsenic from the crude alloy, and arsenic content in the low-arsenic alloy could be decreased to 0. The oxygen concentration and antimony content in the bottom alloy have a significant impact on production efficiency and product quality during blowing oxidation. Chuang, Russell D. Used as a hardening agent in lead bullets, antimony Sb has become a major contaminant in shooting range soils of some countries including Switzerland.

Soil contamination by Sb is also an environmental problem in countries with Sb-mining activities such as China and Bolivia. Because of its toxicity and relatively high mobility, there is concern over the risk of Sb transfer from contaminated soils into plants, and thus into the food chain. In particular there is very little information on the environmental behavior of methylated antimony , which can be produced by microbial biomethylation of inorganic Sb in contaminated soils.

Shoot Sb concentrations, however, did not differ among the three treatments. In contrast, similar concentrations of TMSb were found in the shoots in both inorganic Sb treatments. The results indicate that biomethylation of Sb may occur in plants. In the TMSb treatment TMSb was the major Sb species, but the two inorganic Sb species were also found both in shoots and roots along with some unknown Sb species, suggesting that also TMSb demethylation may occur within plant tissues.

The results furthermore indicate that methylated Sb is more mobile in plants than inorganic Sb species.

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Thiomers inhibited TR with Ki 2. The macrophage uptake was Moreover, the in vitro antileishmanial activity showed These results encouraged the concept that TR and P-gp inhibition by the use of thiomers improves the therapeutic efficacy of antimonial drugs. Chronic exposure to arsenic in drinking water can lead to resistance to antimonial drugs in a mouse model of visceral leishmaniasis.

The Indian subcontinent is the only region where arsenic contamination of drinking water coexists with widespread resistance to antimonial drugs that are used to treat the parasitic disease visceral leishmaniasis. We have previously proposed that selection for parasite resistance within visceral leishmaniasis patients who have been exposed to trivalent arsenic results in cross-resistance to the related metalloid antimony , present in the pentavalent state as a complex in drugs such as sodium stibogluconate Pentostam and meglumine antimonate Glucantime.

To test this hypothesis, Leishmania donovani was serially passaged in mice exposed to arsenic in drinking water at environmentally relevant levels 10 or ppm. Arsenic accumulation in organs and other tissues was proportional to the level of exposure and similar to that previously reported in human liver biopsies. Reassessment of resistant parasites following further passage for 4 mo in mice without arsenic exposure showed that resistance was stable.

Treatment of infected mice with Pentostam confirmed that resistance observed in vitro also occurred in vivo. We conclude that arsenic contamination may have played a significant role in the development of Leishmania antimonial resistance in Bihar because inadequate treatment with antimonial drugs is not exclusive to India, whereas widespread antimonial resistance is.

Low dose systemic or intralesional meglumine antimoniate treatment for American tegumentary leishmaniasis results in low lethality, low incidence of relapse, and low late mucosal involvement in a referral centre in Rio de Janeiro, Brazil American tegumentary leishmaniasis ATL is a non-lethal parasitic disease that presents with cutaneous CL and mucosal ML clinical forms.

ATL treatment aims at healing the lesions and preventing the development of the late mucosal form. Data were recovered from records of all ATL patients diagnosed during that period. Out of patients, were treated with MA Of those, Some patients required additional courses of treatment, thus making a total of courses; Lethality was 0.

As a final outcome for the patients, Alternative MA schedules resulted in low lethality without increase of relapse or late ML incidence. Leishmania major is resistant to the traditional treatments in many parts of the world.

PgpA, a member of ABC transporter superfamily, has been identified in Leishmania involved in antimony resistance. Silymarin can inhibit PgpA. The aim of this study was to determine the effect of combined therapy with glucantime and silymarin on Cutaneous Leishmaniasis. The effects of silymarin on response of L. Immediately after injection in mice inoculated into footpads with L. Silymarin showed no significant effect on the response of L.

The results of this study suggest that silymarin in conjunction with glucantime may have benefit effects in murine model of cutaneous leishmaniasis. Antimony trioxide. For over 60 years, pentavalent antimony Sbv has been the first-line treatment of leishmaniasis. Sickle cell anemia is a disease caused by a defect in red blood cells, which among other things can cause vasooclusive crisis. We report the case of a 6-year-old child with leishmaniasis who during treatment with meglumine antimoniate developed a sickle cell crisis SCC.

No previous reports describing the relationship between antimonial drugs and sickle cell disease were found. Reviews of both the pathophysiology of SCC and the mechanism of action of Sbv revealed that a common pathway glutathione may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sbv, and SCC.

Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sbv caused the SCC. Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. The treatment of cutaneous leishmaniasis is toxic, has contraindications, and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis.

Effectiveness was the proportion of healing and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing was conducted. Average and incremental cost-effectiveness ratios were estimated. The uncertainty regarding effectiveness, safety, and costs was determined through sensitivity analyses.

The therapeutic effectiveness rates were Based on the meta-analysis, thermotherapy may be a dominant strategy. The excellent cost-effectiveness ratio of thermotherapy shows the relevance of its inclusion in guidelines for the treatment. Incidental intrathecal injection of meglumine diatrizoate.

Myelograghy is a process of instilling contrast medium to the subarachnoid space for evaluating the spinal column by radiography. There are various contrast solutions for different radiographic studies but not all of them are suitable for spinal column evaluation.

Our patient was a year-old man who developed severe pain, tonic clonic convulsions and cardiopulmonary arrest after intrathecal injection of 14 mL of meglumine diatrizoate during an elective myelography procedure. Many of these cases would die or suffer from permanent sequelae if appropriate treatment is not received.

Our subject recovered completely without any sequelae after receiving appropriate treatment in a multidisciplinary intensive care unit. Spinal myoclonus following intrathecal administration of diatrizoate meglumine. Rhabdomyolysis and myoglobinuria occurred. The patient was successfully treated with midazolam and vecuronium and complete recovery occurred. Effect of topical honey application along with intralesional injection of glucantime in the treatment of cutaneous leishmaniasis.

Leishmaniasis is an endemic disease in Iran. Although many treatments have been suggested for this disease, there hasn't been an effective and safe treatment yet. Regarding the healing effect of honey in the chronic ulcers and its reported therapeutic effect in cutaneous leishmaniasis, we performed a study to better evaluate the efficacy of honey in cutaneous leishmaniasis and its final scar.

In a prospective clinical trial, patients with confirmed cutaneous leishmaniasis were selected and randomized into 2 groups. Group A were treated with topical honey twice daily along with intralesional injection of glucantime once weekly until complete healing of the ulcer or for maximum of 6 weeks. Group B were treated with intralesional injection of glucantime alone until complete healing of the ulcer or for a maximum of 6 weeks, too.

The patients were followed for 4 months. The collected data were analyzed statistically using statistical tests including Chi-square, Mann Whitney and Kaplan-Mayer tests. In this study, 45 patients that had cutaneous leishmaniasis were treated with intralesional glucantime alone and 45 patients were treated with topical honey and glucantime. Ten patients left out the study. In the glucantime alone treated group, 32 patients Further studies to better clarify the efficacy of honey in cutaneous leishmaniasis is needed.

We suggest that in another study, the efficacy of honey with standardized level of antibacterial activity is evaluated against cutaneous leishmaniasis. Antimony : a flame fighter. In the 11th century, the word antimonium was used by medieval scholar Constantinus Africanus, but antimony metal was not isolated until the 16th century by Vannoccio Biringuccio, an Italian metallurgist. In the early 18th century, chemist Jons Jakob Berzelius chose the periodic symbol for antimony Sb based on stibium, which is the Latin name for stibnite.

Possible links between sickle cell crisis and pentavalent antimony. For over 60 years, pentavalent antimony Sb v has been the first-line treatment of leishmaniasis. Reviews of both the pathophysiology of SCC and the mechanism of action of Sb v revealed that a common pathway glutathione may have resulted in the SCC. ChemoText, a novel database created to predict chemical-protein-disease interactions, was used to perform a more expansive and systematic review that was able to support the association between glutathione, Sb v , and SCC.

Although suggestive evidence to support the hypothesis, additional research at the bench would be needed to prove Sb v caused the SCC. Leishmania is a digenetic protozoan parasite causing leishmaniasis in humans. The different clinical forms of leishmaniasis are caused by more than twenty species of Leishmania that are transmitted by nearly thirty species of phlebotomine sand flies. Pentavalent antimonials such as Pentostam or Glucantime are the first line drugs for treating leishmaniasis.

Recent studies suggest that pentavalent antimony Sb V acts as a pro-drug, which is converted to the more active trivalent form Sb III. However, sensitivity to trivalent antimony varies among different Leishmania species. Leishmania aquaglyceroporin AQP1 facilitates the adventitious passage of antimonite down a concentration gradient.

In this study, we show that Leishmania species causing CL accumulate more antimonite, and therefore exhibit higher sensitivity to antimonials , than the species responsible for VL. This species-specific differential sensitivity to antimonite is directly proportional to the expression levels of AQP1 mRNA.

Effect of diatrizoate meglumine Hypaque on the perilymphatic oxygen tension. The effect of diatrizoate meglumine Hypaque upon the perilymphatic oxygenation has been investigated using the polarographic method in cats submitted to various conditions such as normoxia, apnea, hypercapnia and chronically reduced vascularization.

The minimal changes of the perilymphatic PO2 recorded after the injection of Hypaque permit to conclude that this drug has no practical effect upon the oxygenation of the perilymph. Effects of flunixin meglumine on pregnancy establishment in beef cattle. The objective of this research was to determine effects of a single injection of the prostaglandin synthesis inhibitor Flunixin Meglumine FM; 1. Three experiments were conducted using estrus-synchronized heifers and cows.

Treatment should not exceed 5 consecutive days. The effect of this drug on pregnancy has not been The effect of this drug on pregnancy has not been determined. Not for use in horses intended for food Liposomal amphotericin B versus pentavalent antimony salts for visceral Leishmania in children.

The aim of this study was to investigate the efficacy of a day schedule of liposomal amphotericin B compared to pentavalent antimony salts in the treatment of patients during a first episode of visceral leishmaniasis. The study group was composed of 11 males One group included 11 patients who were treated with pentavalent antimony salts, sodium stibogluconate or meglumine antimoniate , intramuscularly for 28 days.

While pentavalent antimony salts were found to increase biochemical and hematological findings, liposomal amphotericin B was responsible for rapid recovery in fever and shorter hospital stay. As a result, our study shows the advantages of both medications independent of their costs. Meglumine exerts protective effects against features of metabolic syndrome and type II diabetes.

Metabolic syndrome, diabetes and diabetes complications pose a growing medical challenge worldwide, accentuating the need of safe and effective strategies for their clinical management. Here we present preclinical evidence that the sorbitol derivative meglumine N-methyl-D-glucamine can safely protect against several features of metabolic syndrome and diabetes, as well as elicit enhancement in muscle stamina.

Meglumine is a compound routinely used as an approved excipient to improve drug absorption that has not been ascribed any direct biological effects in vivo. Normal mice SV administered 18 mM meglumine orally for six weeks did not display any gastrointestinal or other observable adverse effects, but had a marked effect on enhancing muscle stamina and at longer times in limiting weight gain.

In the established KK. Compared to untreated control animals, meglumine reduced apparent diabetic nephropathy. Sorbitol can improve blood glucose uptake by liver and muscle in a manner associated with upregulation of the AMPK-related enzyme SNARK, but with undesirable gastrointestinal side effects not seen with meglumine. In murine myoblasts, we found that meglumine increased steady-state SNARK levels in a dose-dependent manner more potently than sorbitol. Taken together, these findings provide support for the clinical evaluation of meglumine as a low-cost, safe supplement offering the potential to improve muscle function, limit metabolic syndrome and reduce diabetic complications.

Leishmaniasis is a neglected tropical disease that affects millions of people worldwide and represents a major public health problem. Information on protein expression patterns and functional roles within the context of Leishmania -infected human monocyte-derived macrophages MDMs under drug treatment conditions is essential for understanding the role of these cells in leishmaniasis treatment.

Subcellular localization studies showed a primarily phagolysosomal location for the ABCB5 transporter, indicating that this protein may be involved in the transport of Sb V By inducing a decrease in L. Information on protein expression patterns and functional roles within the context of Leishmania-infected human monocyte-derived macrophages MDMs under drug treatment conditions is essential for understanding the role of these cells in leishmaniasis treatment.

Subcellular localization studies showed a primarily phagolysosomal location for the ABCB5 transporter, indicating that this protein may be involved in the transport of SbV. By inducing a decrease in L. Our results suggest that human MDMs infected with L.

A double-blind, randomized, placebo-controlled, clinical trial was conducted to determine whether the NOP is as effective as Glucantime for the treatment of CL. The cure rates after a 3-month follow-up were Despite the lower efficacy of the NOP versus Glucantime , a significantly lower frequency of non-serious adverse events and a reduced variation in serum markers were observed in patients treated with NOP.

Treatment of CL with NOP resulted in a lower effectiveness compared with Glucantime ; however, the low frequency of adverse events and the facility of topic administration justify the development of new generations of NOP systems for the treatment of CL. Clinical application of oral meglumine diatrizoate esophagogram in screening esophageal fistula during radiotherapy for esophageal cancer.

Esophageal fistula is a serious and common complication of radiotherapy for esophageal cancer. Therefore, early diagnosis and treatment is necessary. Because of side effect of barium esophagography, it cannot be used to screening esophageal fistula during radiotherapy. Meglumine diatrizoate is an ionic contrast agent, its adverse reactions were rarely seen when it was used in the body cavity.

The purpose of this trial is identified the sensitivity and specificity of oral meglumine diatrizoate in an esophagogram for screening esophageal fistula during radiotherapy. This trial was a prospective, multicenter, diagnostic clinical trial. A total of patients with esophageal cancer will swallowed meglumine diatrizoate and underwent a radiographic examination weekly during radiotherapy, medical personnel observed the esophageal lesions to determine whether an esophageal fistula formed.

And the sensitivity and specificity of meglumine diatrizoate should be calculated for screening esophageal fistula during radiotherapy. To our knowledge, this study protocol is the first to identify the sensitivity and specificity of oral meglumine diatrizoate in an esophagogram for screening esophageal fistula during radiotherapy. If oral meglumine diatrizoate can be used to screening esophageal fistula, more patients will benefit from early detection and treatment.

Mineral Resource of the Month: Antimony. Antimony is a lustrous silvery-white semimetal or metalloid. Archaeological and historical studies indicate that antimony and its mineral sulfides have been used by humans for at least six millennia. First principles calculation of two dimensional antimony and antimony arsenide. This work focuses on the strain dependence of the electronic properties of two dimensional antimony Sb material and its alloy with As SbAs using density functional theory based first principles calculations.

Both systems show indirect bandgap semiconducting character which can be transformed into a direct bandgap material with the application of relatively small strain. Geomicrobial interactions with arsenic and antimony. Although arsenic and antimony are generally toxic to life, some microorganisms exist that can metabolize certain forms of these elements. Some can use arsenite or stibnite as potential or sole energy sources, whereas others can use aresenate and antimonite as was discovered only recently as terminal electron acceptors.

Still other microbes can metabolize arsenic and antimony compounds to detoxify them. These reactions are important from a geomicrobial standpoint because they indicate that a number of microbes contribute to arsenic and antimony mobilization or immobilization in the environment and play a role in arsenic and antimony cycles.

Recent reviews include five on prokaryotes and arsenic metabolism, a review with an arsenic perspective on biomining, and a series on environmental antimony , including one about antimony and its interaction with microbiota. Mineral resource of the month: antimony. The article describes the characteristics and industrial uses of antimony. Antimony , which is produced as a byproduct of mining other metals such as gold, lead or silver, is used in everything from flame retardants, batteries, ceramics and glass.

It is also used in glass for television picture tubes, computer monitors, pigments and catalysts. Transdermal flunixin meglumine minimally alters neutrophil functionality in beef heifers administered a respiratory disease challenge.

The objectives were to determine the effects of altering time of transdermal flunixin meglumine BTD; Banamine Transdermal, Merck Animal Health administration relative to a viral-bacterial challenge in beef heifers. Following the September 11, terrorist attacks, letters containing Bacillus anthracis were distributed through the United States postal system killing five people. A complex forensic investigation commenced to identify the perpetrator of these mailings.

Meglumine and diatrizoate are components of radiographic imaging products that have been used to purify bacterial spores. Two separate chromatographic assays using multiple mass spectrometric analyses were developed for the detection of meglumine and diatrizoate. The assays achieved limits of detection for meglumine and diatrizoate of 1.

Bacillus cereus T strain spores were effectively used as a surrogate for B. This protocol was successfully applied to limited evidentiary B. Published This article is a U. Government work and is in the public domain in the U. The use of iohexol in pediatric urography: a comparative study with meglumine diatrizoate.

In a prospective study the nephrotoxicity of iohexol, a new non-ionic contrast medium, was compared with meglumine diatrizoate. Plasma creatinine, BUN, creatinine clearance, urinalysis and the urinary excretion of N-acetyl glucosaminidase NAG , gamma glutamyl transpeptidase GGT and muramidase MU were determined prior to and following intravenous pyelography. A significant rise in the enzyme excretion was observed in patients who received iohexol and diatrizoate.

Statistical analysis failed to demonstrate any difference in nephrotoxicity between the two iodinated contrast media. The effect of in-vivo intravenous administration of sodium meglumine diatrizoate on some haematological parameters. To investigate the in-vivo effects of intravenous administration of sodium meglumine diatrizoate on some haematological parameters in a Nigerian population.

Blood samples were collected before and one hour after intravenous injection of sodium- meglumine diatrizoate from 50 subjects undergoing intravenous urography examinations who had no history of and laboratory confirmed diseases that may affect haematological parameters. Standard laboratory methods were used to assay the haemoglobin concentration Hb , packed cell volume PCV , total white blood cell WBC count and differentials and blood film for any morphological changes in the red blood cells RBC.

Comparisons were made between the mean values of these haematological parameters before and one hour post injection using paired t-test for any statistically significant differences. There were statistically significant reductions in the mean values of Hb concentration and the neutrophil count one hour post injection compared with their pretest values p meglumine diatrizoate causes in-vivo reduction in Hb concentration and neutrophil count in humans as well as poikilocytosis of the erythrocytes.

Some of these effects have the potential of triggering or exacerbating crisis in a sickle cell anaemia subject which is endemic in our locality. Caution should therefore be exercised in the choice and administration of radiological contrast agents to sickle cell subjects. Preparations that are iso-osmolar with plasma and have less probability in precipitating crises should be preferred instead. Characterizing the variability in transcript levels across breeds and sex in swine for genes that play a role in drug metabolism may shed light on breed and sex differences in drug metabolism.

The objective of the study is to determine if there is heterogeneity between swine breeds and sex in transcript levels for genes previously shown to play a role in drug metabolism for animals administered flunixin meglumine or fenbendazole. Animals were randomly placed into the following treatments: no drug control , flunixin meglumine , or fenbendazole. One hour after the second dosing, animals were sacrificed and liver samples collected.

The control animals were used to investigate baseline transcript level differences across breed and sex. Post drug administration transcript differences across breed and sex were investigated by comparing animals administered the drug to the controls. Contrasts to determine fold change were constructed from a model that included fixed and random effects within each drug. Significant P-value meglumine and fenbendazole, respectively.

The current analysis found transcript level differences across swine breeds and sex for multiple genes, which provides greater insight into the relationship between flunixin meglumine and. A year-old Japanese man visited our hospital for chronic abdominal pain, persistent diarrhea and discharge of proglottids for 7 years.

He had been living in Lao People's Democratic Republic. A Taenia saginata including the scolex was excreted through the intestinal tract by the administration of total ml of Gastrografin. Taeniasis is an important disease in the differential diagnosis of imported diseases in Japan. Parasite infection should be suspected in patients with chronic abdominal pain or persistent diarrhea regardless of the findings for small bowel obstruction when there is a history of overseas travel.

Intra-arterial bolus of I labeled meglumine diatrizoate. Early extravascular distribution. A mixture of I labeled meglumine diatrizoate and I labeled human serum albumin was injected into the lower abdominal aorta of 30 anesthetized, laparotomized male rats. Measurements of the activities in cardiac blood and in different tissues of the hindlimbs and tests were perfomed at six time intervals ranging from 5 seconds to 2 minutes after injection, the determine early uptake and distribution volumes of diatrizoate.

Concentrations and distribution volumes were initially much greater than values obtained after intravenous injection, but these differences had considerably decreased or disappeared by 2 minutes. Intravenous bolus of I labeled meglumine diatrizoate.

A mixture of I labeled meglumine diatrizoate and I labeled human serum albumin was injected into the femoral vein of 26 anesthetized male rats. Measurements of the activities in cardiac blood and in different tissues of the lower extremity and in the testis were performed at time intervals ranging from 5 s to 5 min after injection. The determination of tissue uptake and distribution volumes of diatrizoate showed widely differing accumulation of contrast medium.

Over 50 per cent of the intravenous bolus of diatrizoate was extravascular at 40 s. Microbial antimony biogeochemistry: Enzymes, regulation, and related metabolic pathways. Antimony Sb is a toxic metalloid that occurs widely at trace concentrations in soil, aquatic systems, and the atmosphere. Nowadays, with the development of its new industrial applications and the corresponding expansion of antimony mining activities, the phenomenon of antimony pollution has become an increasingly serious concern.

In recent years, research interest in Sb has been growing and reflects a fundamental scientific concern regarding Sb in the environment. In this review, we summarize the recent research on bacterial antimony transformations, especially those regarding antimony uptake, efflux, antimonite oxidation, and antimonate reduction. We conclude that our current understanding of antimony biochemistry and biogeochemistry is roughly equivalent to where that of arsenic was some 20 years ago.

Arsenic and antimony transporters in eukaryotes. Arsenic and antimony are toxic metalloids, naturally present in the environment and all organisms have developed pathways for their detoxification. The most effective metalloid tolerance systems in eukaryotes include downregulation of metalloid uptake, efflux out of the cell, and complexation with phytochelatin or glutathione followed by sequestration into the vacuole.

Understanding of arsenic and antimony transport system is of high importance due to the increasing usage of arsenic-based drugs in the treatment of certain types of cancer and diseases caused by protozoan parasites as well as for the development of bio- and phytoremediation strategies for metalloid polluted areas. However, in contrast to prokaryotes, the knowledge about specific transporters of arsenic and antimony and the mechanisms of metalloid transport in eukaryotes has been very limited for a long time.

Here, we review the recent advances in understanding of arsenic and antimony transport pathways in eukaryotes, including a dual role of aquaglyceroporins in uptake and efflux of metalloids, elucidation of arsenic transport mechanism by the yeast Acr3 transporter and its role in arsenic hyperaccumulation in ferns, identification of vacuolar transporters of arsenic-phytochelatin complexes in plants and forms of arsenic substrates recognized by mammalian ABC transporters.

Characterization of defects in copper antimony disulfide. Copper antimony disulfide CuSbS 2 has several excellent bulk optoelectronic properties for photovoltaic absorber applications. Here, we report on the defect properties in CuSbS 2thin film materials and photovoltaic devices studied using several experimental methods supported by theoretical calculations. Arsenic and Antimony Transporters in Eukaryotes.

Pharmacokinetics of multiple doses of transdermal flunixin meglumine in adult Holstein dairy cows. A transdermal formulation of the nonsteroidal anti-inflammatory drug, flunixin meglumine , has been approved in the United States and Canada for single-dose administration. Transdermal flunixin meglumine was administered to 10 adult Holstein cows in their second or third lactation at the label dose of 3.

Plasma flunixin concentrations were determined using high-pressure liquid chromatography with mass spectroscopy HPLC-MS. Pharmacokinetic analysis was completed on each individual animal with noncompartmental methods using computer software. The time to maximum drug concentration Tmax was 2. The mean accumulation factor was 1. This indicates changes in dosing may not be required when giving multiple doses of flunixin transdermal.

Further work is required to investigate the clinical efficacy of transdermal flunixin after multiple daily doses. Intestinal obstruction and constipation are common conditions in patients with advanced neoplasms. Diatrizoate Meglumine has been used in the management of both these conditions without good quality evidence of its effectiveness and safety. This audit aimed to assess the usage, effectiveness and adverse effects of Diatrizoate Meglumine for intestinal obstruction and constipation in patients with advanced neoplasms.

A retrospective chart review was undertaken. Descriptive statistics were utilised. Seventy-one patients received Diatrizoate Meglumine. The most common diagnoses were ovarian or primary peritoneal neoplasms Diatrizoate Meglumine was most commonly used for intestinal obstruction Diatrizoate Meglumine was well tolerated and may be effective in resolving intestinal obstruction and constipation in patients with advanced neoplasms.

Quality controlled studies are needed to further guide the use of Diatrizoate Meglumine in intestinal obstruction and constipation in patients with advanced neoplasms. Acute metabolic responses to a combined viral-bacterial respiratory disease challenge in heifers administered transdermal flunixin meglumine. A trial was conducted to determine effects of altering time of transdermal flunixin meglumine BTD; Banamine Transdermal, Merck Animal Health, Summit, NJ administration relative to a viral-bacterial respiratory disease challenge in beef heifers.

Acute immunological responses to a combined viral-bacterial respiratory disease challenge in heifers administered transdermal flunixin meglumine. Use of nonimaging nuclear medicine techniques to assess the effect of flunixin meglumine on effective renal plasma flow and effective renal blood flow in healthy horses. The effect of flunixin meglumine on renal function was studied in 6 healthy horses by use of nonimaging nuclear medicine techniques.

Effective renal plasma flow ERPF and effective renal blood flow ERBF were determined by plasma clearance of I-orthoiodohippuric acid before and after administration of flunixin meglumine. Efficacy of pentavalent antimoniate intralesional infiltration therapy for cutaneous leishmaniasis: A systematic review. Background The mainstays of cutaneous leishmaniasis CL treatment, in several world regions, are pentavalent antimony Sbv compounds administered parenterally, despite their recognized toxicity, which requires frequent laboratory monitoring and complicates their use in areas with scarce infrastructure.

As result of these drawbacks, the WHO Expert Committee on leishmaniasis has expanded the recommendations for the use of local therapies, including Sbv intralesional infiltration IL-Sbv , as CL therapy alternatives even in the New World. However, the efficacy of these approaches has never been compiled. The aim of this study was to critically and systematically assess the efficacy of IL-Sbv for CL treatment. The outcome of interest was a clinical cure, defined as complete re-epithelialization of all lesions.

The IL-Sbv pooled cure rate was estimated for several subgroups and direct comparisons were performed when possible. Results Thirty nine articles 40 studies involving patients treated with IL-Sbv infiltration were included. Interaction between antimony atoms and micropores in silicon. Odzhaev, V. The interaction between Sb atoms and micropores of a getter layer in silicon is studied.

The antimony atoms located in the vicinity of micropores are captured by micropores during gettering annealing and lose its electrical activity. The activation energy of capture process to the pores for antimony is lower than that of antimony diffusion in silicon deformation fields around microvoids on the diffusion process.

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches. The aim of this study was to compare the effect of flunixin meglumine FM and meloxicam M on postoperative and oxidative stress in ovariohysterectomized bitches. The concentrations of serum cortisol, nitric oxide NO , malondialdehyde MDA , antioxidant potential AOP and glutation GSH were measured in blood samples collected during incision 0 h , closure of incision line 0.

It was observed that cortisol level was higher at 0. Therefore, it is suggested that postoperative stress following ovariohysterectomy may be prevented by flunixin meglumine. Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration. Appropriate pain management for lameness in swine is a critical control point for veterinarians and producers, but science-based guidance on optimal housing, management and treatment of lameness is deficient.

Results No adverse effects were observed with flunixin meglumine administration for all routes. Flunixin meglumine was administered at an actual mean dose of 2. TMAX was recorded at 1. Conclusions The results of the present study suggest that FM oral administration is not the most effective administration route for mature swine when compared to IV and IM.

Leishmaniasis is a group of diseases that presents various clinical manifestations. Many studies have shown that the parasite plays an important role in the clinical manifestations and prognosis of this disease. The cutaneous and mucosal forms of American tegumentary leishmaniasis ATL are associated with Leishmania Viannia braziliensis, which exhibits intraspecific genetic polymorphisms and various clinical manifestations.

The present study focused on four different L. The isolates were described based on their molecular, biological, and infective characteristics. Complement resistance was evaluated using guinea pig serum. Infection to murine peritoneal macrophages, cytokine and nitric oxide were analyzed. Ultrastructural features were determined by transmission electron microscopy, and molecular characteristics were determined based on random amplified polymorphic DNA RAPD.

All of the L. Markedly lower infectivity indexes were observed for all strains in the LOG phase, with different cytokine profiles. We report the effects of antimony Sb doping on the electrical and optical properties of amorphous carbon a-C:H films grown on silicon and copper substrates by magnetron sputtering deposition. For film deposition, the mixture targets fabricated from carbon and antimony powders was used. The atomic concentration of carbon, hydrogen, and antimony , in the film deposited from the 1.

These elements were homogeneously distributed in the film. On the structural effect, the average continuous sp2 carbon bonding networks decreased with Sb concentration increasing, and defects in the films were increased with the Sb incorporation because atomic radius of Sb atoms is twice larger size than that of carbon. The optical gap and the electrical resistivity were carried out before and after the Sb doping.

The results show that optical gap dropped from 3. The electrical resistivity reduced from These results suggest the doping level was newly formed in the forbidden band. Serum electrolyte and protein changes after intravenous injection of sodium and meglumine diatrizoate urograffin Serum electrolyte and protein changes in 35 Nigerian patients undergoing intravenous urography were evaluated after injection of 60 mls sodium and meglumine diatrizoate Urograffin Statistically, significant changes were noted in the values of serum calcium, proteins and albumin at 5 and 30 minutes after the injection P A Pharmacokinetics, Efficacy, and Safety Study of Gadoterate Meglumine in Pediatric Subjects Aged Younger Than 2 Years.

Objectives The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. Material and Methods This was a Phase IV open-label, prospective study conducted in 9 centers 4 countries. Forty-five patients younger than 2 years with normal estimated glomerular filtration rate and scheduled to undergo routine gadolinium-enhanced magnetic resonance imaging MRI of any organ were included and received a single intravenous injection of gadoterate meglumine 0.

To perform the population pharmacokinetics analysis, 3 blood samples per subject were drawn during 3 time windows at time points allocated by randomization. Results Gadoterate meglumine concentrations were best fitted using a 2-compartmental model with linear elimination from central compartment.

The median total clearance adjusted to body weight was estimated at 0. The median volume of distribution at steady state Vss adjusted to body weight was estimated at 0. Lesion visualization was improved with a mean SD increase in scores at subject level of 0.

Twenty-six adverse events occurred postinjection in 13 subjects The primary objective of this study was to investigate the pharmacokinetic profile of gadoterate meglumine in pediatric patients younger than 2 years; the secondary objectives were to document its efficacy and safety. This was a Phase IV open-label, prospective study conducted in 9 centers 4 countries.

Gadoterate meglumine concentrations were best fitted using a 2-compartmental model with linear elimination from central compartment. One subject 2. In vitro antileishmanial activity of fisetin flavonoid via inhibition of glutathione biosynthesis and arginase activity in Leishmania infantum. With the increasing emergence of drug resistant Leishmania sp. The present study was designed to evaluate the antileishmanial effects of the fisetin alone and combination of fisetin plus Meglumine antimoniate Fi-MA against Leishmania infantum.

The IC50 values for fisetin were obtained 0. The decreased levels of most of the antioxidant enzymes, accompanying by the raised level of NO in treated macrophages with MA, were observed to regain their normal profiles due to Fi-MA treatment. In conclusion, these findings showed that fisetin improves MA side effects. The exposure to and health effects of antimony. Context: This minireview describes the health effects of antimony exposure in the workplace and the environment.

Aim: To collate information on the consequences of occupational and environmental exposure to antimony on physiological function and well-being. Methods: The criteria used in the current minireview for selecting articles were adopted from proposed criteria in The International Classification of Functioning, Disability and Health. Articles were classified from an acute and chronic exposure and toxicity thrust. Results: The proportion of utilised and non-utilised articles was tabulated.

Antimony toxicity is dependent on the exposure dose, duration, route breathing, eating, drinking, or skin contact , other chemical exposures, age, sex, nutritional status, family traits, life style, and state of health. Long-term inhalation of antimony can potentiate pneumoconiosis, altered electrocardiograms, stomach pain, diarrhea, vomiting, and stomach ulcers, results which were confirmed in laboratory animals. Although there were investigations of the effect of antimony in sudden infant death syndrome, current findings suggest no link.

Antimony trioxide exposure is predominant in smelters. Mining and exposure via glass working, soldering, and brazing are also important. Conclusion: Antimony has some useful but undoubtedly harmful effects on health and well-being and measures need to be taken to prevent hazardous exposure of the like.

Its biological monitoring in the workplace is essential. The first line drug against leishmaniasis consists of pentavalent antimony [Sb V ], but there is general belief that the active form of the metal is the trivalent form [Sb III ]. In this study, we have quantified the accumulation of Sb V and Sb III in Leishmania by using inductively coupled plasma mass spectrometry.

The accumulation was studied in three Leishmania species at various life stages, sensitive or resistant to antimony. The level of accumulation of either Sb III or Sb V , however, was not correlated with the susceptibility of wild-type Leishmania cells to antimony. This suggests that other factors may also be implicated in the mode of action of the drugs.

In contrast to metal susceptibility, resistance to Sb III correlated well with decreased antimony accumulation. This phenotype was energy dependent and highlights the importance of transport systems in drug resistance of this protozoan parasite. Comparison of the excretion of sodium and meglumine diatrizoate at urography with simulated compression: an experimental study in the rat. In the experimental model in the rabbit the excretion of sodium and meglumine diatrizoate, respectively, have been compared.

More reliable dose optima are probably found when calculating density rather than determining urine concentrations. Examining the occurrence of residues of flunixin meglumine in cull dairy cows by use of the flunixin cull cow survey. To determine whether cull dairy cows with signs of certain clinical conditions, termed suspect, are more likely than healthy-appearing cull dairy cows to have violative concentrations of flunixin meglumine in their tissues at slaughter.

Cross-sectional study. Suspect cull dairy cows were selected from 21 beef slaughter establishments with a high production volume of dairy cows, and kidney and liver tissues were collected for screening. Kidney tissues were screened for antibiotics and sulfonamides with the fast antimicrobial screening test FAST. During the same time period, liver tissues from healthy-appearing cull dairy cows were collected for the Food Safety and Inspection Service National Residue Program Scheduled Sampling Plan, but were screened only for flunixin meglumine.

Of suspect cull dairy cows, 50 7. Thirty-one of Two of the 0. Suspect cull dairy cows, especially those that were also FAST positive, had a significantly higher incidence of violative tissue flunixin concentrations than healthy-appearing cull dairy cows at slaughter. Targeted sampling plans for flunixin meglumine in suspect dairy cows can help to support more efficient use of resources and further safeguard the nation's food supply.

Prospective randomized trial of iohexol versus meglumine sodium diatrizoate as an oral contrast agent for abdominopelvic computed tomography. To compare the efficacy and patient tolerance of iohexol and meglumine sodium diatrizoate as oral contrast agents for computed tomography CT. One hundred patients were randomly assigned to drink mL of either meglumine sodium diatrizoate or iohexol before their abdominopelvic CT examination.

The images were evaluated independently and in a blinded fashion by 2 radiologists who scored the extent and density of bowel opacification. Attenuation value measurements were obtained in representative areas of each gastrointestinal tract segment stomach, duodenum, jejunum, ileum, and colon by a research technologist. Patients' tolerance of the oral contrast agent was assessed through a questionnaire administered immediately after the CT and with a follow-up phone call 2 to 3 days later.

For most of the bowel, there was no statistically significant difference in the extent or degree of opacification between the 2 contrast agents. Opacification of the ileum was better with iohexol. There was no statistically significant difference between the 2 agents in adverse effects. Patients had a small but statistically significant preference for the taste of iohexol. Iohexol is a satisfactory oral contrast agent for abdominopelvic CT.

It opacifies the gastrointestinal tract as well as meglumine sodium diatrizoate does, and patients prefer the taste of iohexol to that of diatrizoate. Antimony diffusion in CdTe. Group V dopants may be used for next-generation high-voltage cadmium telluride CdTe solar photovoltaics, but fundamental defect energetics and kinetics need to be understood.

Here, antimony Sb diffusion is studied in single-crystal and polycrystalline CdTe under Cd-rich conditions. Diffusion profiles are determined by dynamic secondary ion mass spectroscopy and analyzed with analytical bulk and grain-boundary diffusion models.

Slow bulk and fast grain-boundary diffusion are found. Density functional theory is used to understand formation energy and mechanisms. Lastly, the theory and experimental results create new understanding of group V defect kinetics in CdTe. Effect of flunixin meglumine and carprofen on pregnancy rates in dairy cattle. Embryonic losses contribute considerably to low pregnancy rates. Flunixin meglumine FM has been demonstrated to delay luteolysis and to support embryonic survival.

The objective of this study was to evaluate the effect of FM and carprofen on conception rates in dairy heifers and cows, respectively. In experiment 1, the effect of FM on pregnancy rates and progesterone concentrations in dairy heifers was tested. A total of heifers were randomly assigned to 1 of 2 groups. Pregnancy rates were In experiment 2, the objective was to verify the effects of carprofen, a longer acting nonsteroidal antiinflammatory drug and to evaluate its effect on conception rate to first service in dairy cows.

A total of cows were randomly assigned to 1 of 2 treatment groups. Pregnancy was diagnosed between d 40 and 47 after insemination. Conception rates to first service were Nuclear orientation of antimony and bromine isotopes. The technique of Low Temperature Nuclear Orientation has been used to study neutron deficient antimony and bromine isotopes.

Further anisotropy measurements on [ The magnetic moment of [72]Br has been limited to be within the range 0. Leishmaniasis is a disease that affects 2 million people and kills persons every year. It is caused by Leishmania species, which are human protozoan parasites of the trypanosomatidae family. The current treatment of leishmaniasis relies mainly on antimonial drugs. The crystal structures of oxidized trypanothione reductase TR from Leishmania infantum and of the complex of reduced TR with NADPH and Sb III , reported in this paper, disclose for the first time the molecular mechanism of action of antimonial drugs against the parasite.

Sb III , which is coordinated by the two redox-active catalytic cysteine residues Cys52 and Cys57 , one threonine residue Thr , and His' of the 2-fold symmetry related subunit in the dimer, strongly inhibits TR activity. Because TR is essential for the parasite survival and virulence and it is absent in mammalian cells, these findings provide insights toward the design of new more affordable and less toxic drugs against Leishmaniasis.

Antimony ore in the Fairbanks district, Alaska. Antimony -bearing ores in the Fairbanks district, Alaska, are found principally in two areas, the extremities of which are at points 10 miles west and 23 miles northeast of Fairbanks; and one of two minor areas lies along this same trend 30 miles farther to the northeast. These areas are probably only local manifestations of mineralization that affected a much broader area and formed antimony -bearing deposits in neighboring districts, the closest of which is 50 miles away.

The ores were exposed largely as a result of lode gold mining, but at two periods in the past, high prices for antimony ore warranted an independent production and about tons of stibnite ore was shipped. The sulfide deposits occupy the same fractures along which a gold-quartz mineralization of greater economic importance occurred; and both are probably genetically related to igneous rocks which intrude the schistose country rock.

The sulfide is in part contemporaneous with some late-stage quartz in which it occurs as disseminated crystals; and in part the latest filling in the mineralized zones where it forms kidney-shaped masses of essentially solid sulfide. One extremely long mass must have contained nearly tons of ore, but the average of the larger kidneys is closer to several tons. Much of the ore is stibnite, with quartz as a minor impurity, and assays show the tenor to vary from 40 to 65 percent antimony.

Sulphantimonites are less abundant but likewise occur as disseminated crystals and as kidney-shaped bodies. Antimony oxides appear on the weathered surface and along fractures within the sulfide ore. Deposits containing either stibnite or sulphantimonite are known at more than 50 localities, but only eighteen have produced ore and the bulk of this came from the mines.

The geology of the deposit, and the nature, extent, and period of the workings are covered in the detailed descriptions of individual occurrences. Several geologic and economic factors, which greatly affect. The creation and exchange of biologically relevant models is of great interest to many researchers. When multiple standards are in use, models are more readily used and re-used if there exist robust translators between the various accepted formats.

Antimony 2. All provided unique challenges, stemming from differences in each format's inherent design, in addition to differences in functionality. Topical terbinafine in the treatment of cutaneous leishmaniasis: triple blind randomized clinical trial. Leishmaniasis is a spectrum of disease condition with considerable health impacts, caused by different species of Leishmania.

This disease is currently endemic in 98 countries and territories in the world. There are many treatment modalities for cutaneous leishmaniasis.

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